van der Schaar Lab

Revolutionizing Healthcare: how can AI/ML transform organ transplantation?

The van der Schaar Lab’s twelfth Revolutionizing Healthcare engagement session for clinicians took place virtually on November 30, 2021.

In this session, Mihaela van der Schaar and a panel of 4 international clinicians explored possible AI and machine learning approaches to organ transplantation.

Our panel for this session consisted of:

  • Alexander Gimson, MD FRCP (Transplant hepatologist (Cambridge); working with the van der Schaar Lab)
  • Gabriel Oniscu, MD FRCS (Consultant transplant surgeon and honorary reader in transplantation, Royal Infirmary of Edinburgh; Clinical director, Edinburgh Transplant Centre)
  • Martin Cadeiras, MD (Associate professor, medical director, heart failure, heart transplantation and mechanical circulatory support, University of California, Davis)
  • Prof. Michael Nicholson, MD DSc FRCS (Professor of transplant surgery & head of the Division of Academic General & Transplant Surgery, University of Cambridge; Director, NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation)

In the first part of the session, Dr. Alexander Gimson, a Cambridge-based transplant hepatologist, outlined the importance, complexities, and unique challenges of the organ transplantation setting, while also highlighting some recent collaborative projects using machine learning for donor-recipient matchmaking and survival prediction. The latter part of the session featured a clinician roundtable comprising an expert panel of four transplantation specialists. Our panelists answered an array of questions (most of which came from the audience) and discussed the path forward for AI and machine learning for organ transplantation.

Introduction – 0:00
Declaration of interests – 0:38
Session overview – 1:42
Meet the roundtable panelists – 4:20
Presentation by Mihaela: “Getting ML-powered tools into the hands of clinicians – part 3” – 6:02
Alexander Gimson: “AI for transplantation: initial results, future proposals” – 13:24
Alexander Gimson: OrganBoard demonstrator and case studies – 29:09
Roundtable topic 1: what should we focus on next? – 33:26
Roundtable topic 2: how has organ transplantation evolved in recent years? – 35:34
Roundtable topic 3: how can we empower surgeons in the transplant setting? – 39:40
Roundtable topic 4: rethinking standards for measuring outcomes – 47:00
Roundtable topic 5: sensitivity to patient trajectory – 50:29
Roundtable topic 6: taking into account regional variation in transplant practices – 58:05
Roundtable topic 7: determining benefit of transplantation vs. conservative approaches – 1:01:01
Intro to next sessions and note on CPD credits – 1:06:22

NOTE: This information was up-to-date at the time of the presentation but does not take into account material published since then.

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Nick Maxfield

Nick oversees the van der Schaar Lab’s communications, including media relations, content creation, and maintenance of the lab’s online presence.

Nick studied Japanese (BA Hons.) at the University of Oxford, graduating in 2012. Nick previously worked in HQ communications roles at Toyota (2013-2016) and Nissan (2016-2020).

Given his humanities/languages background and experience in communications, Nick is well-positioned to highlight and explain the real-world impact of research that can often be quite esoteric. Thankfully, he is comfortable asking almost endless questions in order to understand a topic.